ACE-031 1 mg

ACE-031 (Ramatercept) is a soluble fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) linked to a human IgG1-Fc region. By acting as a decoy receptor (‘ligand trap’), it sequesters multiple TGF-β superfamily ligands — myostatin, activin A/B, GDF-11, BMP-9, BMP-10 — preventing their binding to native ACVR2B. Research applications include broad TGF-β superfamily pathway investigation, myostatin/activin pathway dissection, and ligand trap pharmacology.