GnRH (Triptorelin) 2mg

Triptorelin (D-Trp6-LHRH) is a decapeptide GnRH analogue with a single D-tryptophan substitution at position 6 that confers greater GnRHR binding affinity and substantially extended plasma half-life relative to gonadorelin. Unlike native GnRH (which requires pulsatile delivery to sustain gonadotropin secretion), triptorelin’s extended half-life produces continuous GnRHR engagement — driving initial gonadotropin surge followed by receptor downregulation and sustained HPG-axis suppression. Research applications include GnRHR pharmacology, HPG-axis suppression modelling, chemical castration models, and GnRH analogue comparative pharmacology.