YK-11 is a synthetic steroidal compound that functions as a gene-selective partial agonist of the androgen receptor (AR). Experimental investigations have reported interactions with androgen receptor-mediated transcriptional regulation together with modulation of follistatin (FST)-associated gene expression pathways. Follistatin is a regulatory glycoprotein involved in activin-associated signaling networks and transcriptional control processes, making YK-11 a useful research tool for examining AR-dependent gene regulation and downstream signaling mechanisms.
Research applications include androgen receptor pharmacology, AR partial agonism studies, follistatin-associated pathway investigation, transcriptional regulation research, structure-activity relationship analysis, and mechanistic comparison of steroidal and non-steroidal androgen receptor modulators.



